间充质干细胞
自愈水凝胶
3D生物打印
明胶
细胞外基质
材料科学
再生医学
组织工程
纳米技术
透明质酸
生物医学工程
干细胞
化学
细胞生物学
解剖
生物
医学
高分子化学
生物化学
作者
Seok Hyun Lee,Moon Sung Kang,Sangheon Jeon,Hyo Jung Jo,Suck Won Hong,Bongju Kim,Dong‐Wook Han
出处
期刊:Heliyon
[Elsevier]
日期:2023-03-01
卷期号:9 (3): e14490-e14490
被引量:18
标识
DOI:10.1016/j.heliyon.2023.e14490
摘要
Contemporary advances in three-dimensional (3D) bioprinting technologies have enabled the fabrication of tailored live 3D tissue mimetics. Furthermore, the development of advanced bioink materials has been highlighted to accurately reproduce the composition of a native extracellular matrix and mimic the intrinsic properties of laden cells. Recent research has shown that MXene is one of promising nanobiomaterials with osteogenic activity for bone grafts and scaffolds due to its unique atomic structure of three titanium layers between two carbon layers. In this study, the MXene-incorporated gelatin methacryloyl (GelMA) and hyaluronic acid methacryloyl (HAMA) (i.e., GelMA/HAMA-MXene) bioinks were prepared to explore if they have the potential to enable the spontaneous osteodifferentiation of human mesenchymal stem cells (hMSCs) when the hMSCs-laden GelMA/HAMA-MXene bioinks were 3D printed. The physicochemical and rheological characteristics of the GelMA/HAMA-MXene hydrogels were proven to be unprecedentedly favorable supportive matrices suited for the growth and survival of hMSCs. Furthermore, hMSCs were shown to spontaneously differentiate into osteoblasts within GelMA-HAMA/MXene composites to provide favorable microenvironments for osteogenesis. Therefore, our results suggest that the remarkable biofunctional advantages of the MXene-incorporated GelMA/HAMA bioink can be utilized in a wide range of strategies for the development of effective scaffolds in bone tissue regeneration.
科研通智能强力驱动
Strongly Powered by AbleSci AI