周边公差
生物
免疫耐受
自我容忍
效应器
免疫系统
中心公差
免疫学
功能(生物学)
抗原
口服耐受性
免疫耐受
T细胞
细胞生物学
全生物
克隆缺失
遗传学
T细胞受体
细菌
共生
作者
Chrysothemis C. Brown,Alexander Y. Rudensky
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-05-05
卷期号:380 (6644): 472-478
被引量:8
标识
DOI:10.1126/science.adg6425
摘要
The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to establish tolerance to the holobiont self, which comprises a highly complex community of commensal microorganisms. Here, we review recent advances in the investigation of peripheral T cell tolerance, focusing on new insights into mechanisms of tolerance to the gut microbiota, including tolerogenic antigen-presenting cell types and immunomodulatory lymphocytes, and their layered ontogeny that underlies developmental windows for establishing intestinal tolerance. While emphasizing the intestine as a model tissue for studying peripheral T cell tolerance, we highlight overlapping and distinct pathways that underlie tolerance to self-antigens versus commensal antigens within a broader framework for immune tolerance.
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