Impedance-based polymer microneedle patch sensor for continuous interstitial fluid glucose monitoring

生物医学工程 持续监测 间质液 葡萄糖氧化酶 连续血糖监测 材料科学 电阻抗 渗透(战争) 医学 生物传感器 纳米技术 糖尿病 病理 1型糖尿病 电气工程 经济 内分泌学 运营管理 工程类 运筹学
作者
Honglin Piao,Yongho Choi,Jae Hyun Kim,Daerl Park,Lee Jia,Dahl‐Young Khang,Heon‐Jin Choi
出处
期刊:Biosensors and Bioelectronics [Elsevier BV]
卷期号:247: 115932-115932
标识
DOI:10.1016/j.bios.2023.115932
摘要

Early detection and effective blood glucose control are critical for preventing and managing diabetes-related complications. Conventional glucometers provide point-in-time measurements but are painful and cannot facilitate continuous monitoring. Continuous glucose monitoring systems are comfortable but face challenges in terms of accuracy, cost, and sensor lifespan. This study aimed to develop a microneedle-based sensor patch for minimally invasive, painless, and continuous glucose monitoring in the interstitial fluid to address these limitations. Experimental results confirm painless and minimally invasive penetration of the skin tissue with cylindrical microneedles (3 × 3 array) to a depth of approximately 520 μm with minimal loading. The microneedle sensors fabricated with precision using the complementary metal-oxide semiconductor process were immobilized with glucose oxidase, as confirmed through phase angle analysis. Long-term tests confirmed the effective operation of the sensor for up to seven days. Glucose concentrations determined from the fitted concentration-impedance curves correlated well with those measured using commercial glucometers, indicating the reliability and precision of the microneedle sensor. The flexible and minimally invasive sensor developed in this study facilitates painless and continuous glucose monitoring.
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