Protein Design Using Structure-Prediction Networks: AlphaFold and RoseTTAFold as Protein Structure Foundation Models

Jue Wang1,2,3,4, Joseph L. Watson1,2 and Sidney L. Lisanza1,2,3 1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA 2Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA 3Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, Washington 98195, USA 4DeepMind, London EC4A 3BF, United Kingdom Correspondence: juewang{at}post.harvard.edu