Safety and Virologic Impact of Haploidentical NK Cells Plus Interleukin 2 or N-803 in HIV Infection
免疫学
人类免疫缺陷病毒（HIV）
病毒学
医学
作者
Jeffrey S. Miller,Joshua Rhein,Zachary Davis,Sarah Cooley,David H. McKenna,Jodi Anderson,Kevin Escandón-Vargas,Garritt Wieking,Jarrett Reichel,Ann Thorkelson,Siri Jorstad,Jeffrey T. Safrit,Patrick Soon‐Shiong,Gregory J. Beilman,Jeffrey G. Chipman,Timothy W. Schacker
Natural killer (NK) cells are dysfunctional in chronic human immunodeficiency virus (HIV) infection as they are not able to clear virus. We hypothesized that an infusion of NK cells, supported by interleukin 2 (IL-2) or IL-15, could decrease virus-producing cells in the lymphatic tissues.
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