生物
小胶质细胞
视网膜
细胞生物学
细胞内
细胞凋亡
细胞
神经胶质
神经科学
免疫学
炎症
中枢神经系统
遗传学
作者
Michael J. Morales,Anna P. Findley,Diana M. Mitchell
出处
期刊:Development
[The Company of Biologists]
日期:2024-01-01
卷期号:151 (1)
被引量:3
摘要
To clarify our understanding of glial phagocytosis in retinal development, we used real-time imaging of larval zebrafish to provide cell-type specific resolution of this process. We show that radial Müller glia frequently participate in microglial phagocytosis while also completing a subset of phagocytic events. Müller glia actively engage with dying cells through initial target cell contact and phagocytic cup formation, after which an exchange of the dying cell from Müller glia to microglia often takes place. In addition, we find evidence that Müller glia cellular material, possibly from the initial Müller cell phagocytic cup, is internalized into microglial compartments. Previously undescribed Müller cell behaviors were seen, including cargo splitting, wrestling for targets and lateral passing of cargo to neighbors. Collectively, our work provides new insight into glial functions and intercellular interactions, which will allow future work to understand these behaviors on a molecular level.
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