Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors

免疫原性 药物输送 医学 免疫系统 癌症研究 纳米技术 免疫学 材料科学
作者
Keshuang Zheng,Yongpu Feng,Lie Li,Fanyang Kong,Jie Gao,Xiangyu Kong
出处
期刊:Theranostics [Ivyspring International Publisher]
卷期号:14 (2): 761-787 被引量:16
标识
DOI:10.7150/thno.85917
摘要

Outer membrane vesicles (OMVs) are nanoscale lipid bilayer structures released by gram-negative bacteria.They share membrane composition and properties with their originating cells, making them adept at traversing cellular barriers.These OMVs have demonstrated exceptional membrane stability, immunogenicity, safety, penetration, and tumor-targeting properties, which have been leveraged in developing vaccines and drug delivery systems.Recent research efforts have focused on engineering OMVs to increase production yield, reduce cytotoxicity, and improve the safety and efficacy of treatment.Notably, gastrointestinal (GI) tumors have proven resistant to several traditional oncological treatment strategies, including chemotherapy, radiotherapy, and targeted therapy.Although immune checkpoint inhibitors have demonstrated efficacy in some patients, their usage as monotherapy remains limited by tumor heterogeneity and individual variability.The immunogenic and modifiable nature of OMVs makes them an ideal design platform for the individualized treatment of GI tumors.OMV-based therapy enables combination therapy and optimization of anti-tumor effects.This review comprehensively summarizes recent advances in OMV engineering for GI tumor therapy and discusses the challenges in the clinical translation of emerging OMV-based anti-tumor therapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3-HP完成签到,获得积分10
刚刚
失眠的向日葵完成签到 ,获得积分10
1秒前
Baneyhua完成签到,获得积分10
1秒前
2秒前
深情安青应助默默菲音采纳,获得30
2秒前
zhouleiwang完成签到,获得积分10
3秒前
pinkdon完成签到,获得积分10
3秒前
123完成签到,获得积分0
3秒前
舒心如凡完成签到,获得积分10
3秒前
4秒前
闪蓝之光完成签到,获得积分10
6秒前
无花果应助Liang采纳,获得10
6秒前
有志者发布了新的文献求助30
7秒前
8秒前
10秒前
脑洞疼应助赵哈哈找文献采纳,获得10
12秒前
满意涵梅发布了新的文献求助10
12秒前
McSee完成签到,获得积分10
13秒前
13秒前
兰lanlan发布了新的文献求助10
15秒前
凭亿近人发布了新的文献求助10
15秒前
16秒前
16秒前
wushengdeyu完成签到,获得积分10
17秒前
YLT完成签到,获得积分10
17秒前
FOX完成签到,获得积分10
18秒前
18秒前
Liang发布了新的文献求助10
19秒前
缓慢如南应助燕子采纳,获得10
19秒前
淳于无施完成签到,获得积分10
19秒前
HM发布了新的文献求助10
20秒前
科研菜鸡完成签到 ,获得积分10
21秒前
21秒前
22秒前
rio完成签到 ,获得积分10
22秒前
盛世如愿发布了新的文献求助10
25秒前
25秒前
QMCL完成签到,获得积分10
26秒前
黑糖珍珠完成签到 ,获得积分10
29秒前
会飞的金鱼完成签到,获得积分10
29秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 720
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3567156
求助须知:如何正确求助?哪些是违规求助? 3139675
关于积分的说明 9432949
捐赠科研通 2840458
什么是DOI,文献DOI怎么找? 1561046
邀请新用户注册赠送积分活动 730189
科研通“疑难数据库(出版商)”最低求助积分说明 717869