医学
血液透析
心脏病学
缺血
入射(几何)
内科学
肾脏疾病
重症监护医学
人口
疾病
环境卫生
光学
物理
作者
Christopher W. McIntyre
出处
期刊:Journal of The American Society of Nephrology
日期:2024-01-26
卷期号:35 (5): 653-664
被引量:2
标识
DOI:10.1681/asn.0000000000000299
摘要
Hemodialysis is a life-saving treatment for patients with kidney failure. However, patients requiring hemodialysis have a 10–20 times higher risk of cardiovascular morbidity and mortality than that of the general population. Patients encounter complications such as episodic intradialytic hypotension, abnormal perfusion to critical organs (heart, brain, liver, and kidney), and damage to vulnerable vascular beds. Recurrent conventional hemodialysis exposes patients to multiple episodes of circulatory stress, exacerbating and being aggravated by microvascular endothelial dysfunction. This promulgates progressive injury that leads to irreversible multiorgan injury and the well-documented higher incidence of cardiovascular disease and premature death. This review aims to examine the underlying pathophysiology of hemodialysis-related vascular injury and consider a range of therapeutic approaches to improving outcomes set within this evolved rubric.
科研通智能强力驱动
Strongly Powered by AbleSci AI