已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Neuroprotective properties of plant extract green-formulated silver nanoparticles on the contusive model of spinal cord injury in rats

神经保护 脊髓损伤 脊髓 药理学 传统医学 医学 麻醉 化学 神经科学 生物
作者
Yu Zhang,Peixin Wang,Shiyu Feng
出处
期刊:Inorganic Chemistry Communications [Elsevier BV]
卷期号:163: 112265-112265 被引量:1
标识
DOI:10.1016/j.inoche.2024.112265
摘要

Silver nanoparticles (Ag NPs) are highly sought-after metal nanoparticles globally due to their distinctive electronic and optical characteristics, as well as their biological properties. These attributes stem from the synchronized movements of conduction electrons, referred to as surface plasmon resonance. Currently, numerous bio-medical characteristics of biosynthesized Ag nanoparticles have been thoroughly documented, including their anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Nevertheless, there have been no reports regarding the neuroprotective efficacy of these nanoparticles against cytotoxic agents. It appears that the defensive capabilities of the NPs formulated by green methods have been disregarded thus far. We recently did research to assess the neuroprotective effects of a combination of Tribulus terrestris and green-mediated silver nanoparticles on a contusive spinal cord injury model in animals. The silver nanoparticles underwent comprehensive characterization through UV–Vis, FE-SEM, FT-IR, and TEM analyses. In the in vivo phase of the research, a total of forty rats were categorized into three groups: untreated, normal, and silver nanoparticles (50 µg/kg) groups. The post-injury lesions were analyzed using H&E staining. To evaluate the restoration of neural conduction, somatosensory evoked potential testing was conducted. The presence of astrogliosis was determined by evaluating the expression of GFAP. The rats' behavioral outcomes were assessed using the BBB score every week. The utilization of silver nanoparticles demonstrated neuroprotective properties and resulted in enhancements in spinal cord injury. The results of the sensory assessments indicated a notable rise in the Basso, Beattie, and Bresnahan scales, along with a marked decline in delayed reactions, among the subjects who received treatment with silver nanoparticles. The most substantial decrease in GFAP levels was noted in the group that was administered silver nanoparticles. Furthermore, there was a substantial decrease in the size of the cavity regions, while the quantity of ventral motor neurons experienced a significant rise within the silver nanoparticles group. The electromyography (EMG) results demonstrated a remarkable enhancement in the hindlimbs of the subjects who received treatment with silver nanoparticles (50 µg/kg).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
华仔应助科研通管家采纳,获得10
1秒前
Ava应助科研通管家采纳,获得10
1秒前
赘婿应助科研通管家采纳,获得10
1秒前
1秒前
思源应助科研通管家采纳,获得10
2秒前
科研通AI5应助科研通管家采纳,获得10
2秒前
我是老大应助科研通管家采纳,获得10
2秒前
YY发布了新的文献求助10
3秒前
脑洞疼应助SUE采纳,获得10
4秒前
4秒前
恒星的恒心完成签到 ,获得积分10
6秒前
IvyLee完成签到,获得积分10
7秒前
8秒前
00完成签到,获得积分10
8秒前
kangw发布了新的文献求助10
12秒前
Linbo完成签到,获得积分10
14秒前
瓶盖完成签到 ,获得积分10
16秒前
某某辣酱发布了新的文献求助10
17秒前
喜悦香薇完成签到 ,获得积分10
20秒前
21秒前
24秒前
俊逸海豚完成签到 ,获得积分10
25秒前
隐形曼青应助chen采纳,获得10
26秒前
kangw完成签到,获得积分20
27秒前
曹大壮发布了新的文献求助10
28秒前
小谢完成签到,获得积分10
29秒前
饭ff发布了新的文献求助10
29秒前
执着的冬瓜完成签到 ,获得积分10
29秒前
31秒前
32秒前
DAYDAY完成签到 ,获得积分10
37秒前
37秒前
xcf驳回了orixero应助
38秒前
Nowind发布了新的文献求助10
39秒前
40秒前
41秒前
111完成签到,获得积分10
41秒前
健壮保温杯完成签到,获得积分10
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989868
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255752
捐赠科研通 3270793
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882215
科研通“疑难数据库(出版商)”最低求助积分说明 809208