Neuroprotective properties of plant extract green-formulated silver nanoparticles on the contusive model of spinal cord injury in rats

神经保护 脊髓损伤 脊髓 药理学 传统医学 医学 麻醉 化学 神经科学 生物
作者
Yu Zhang,Peixin Wang,Shiyu Feng
出处
期刊:Inorganic Chemistry Communications [Elsevier BV]
卷期号:163: 112265-112265 被引量:1
标识
DOI:10.1016/j.inoche.2024.112265
摘要

Silver nanoparticles (Ag NPs) are highly sought-after metal nanoparticles globally due to their distinctive electronic and optical characteristics, as well as their biological properties. These attributes stem from the synchronized movements of conduction electrons, referred to as surface plasmon resonance. Currently, numerous bio-medical characteristics of biosynthesized Ag nanoparticles have been thoroughly documented, including their anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Nevertheless, there have been no reports regarding the neuroprotective efficacy of these nanoparticles against cytotoxic agents. It appears that the defensive capabilities of the NPs formulated by green methods have been disregarded thus far. We recently did research to assess the neuroprotective effects of a combination of Tribulus terrestris and green-mediated silver nanoparticles on a contusive spinal cord injury model in animals. The silver nanoparticles underwent comprehensive characterization through UV–Vis, FE-SEM, FT-IR, and TEM analyses. In the in vivo phase of the research, a total of forty rats were categorized into three groups: untreated, normal, and silver nanoparticles (50 µg/kg) groups. The post-injury lesions were analyzed using H&E staining. To evaluate the restoration of neural conduction, somatosensory evoked potential testing was conducted. The presence of astrogliosis was determined by evaluating the expression of GFAP. The rats' behavioral outcomes were assessed using the BBB score every week. The utilization of silver nanoparticles demonstrated neuroprotective properties and resulted in enhancements in spinal cord injury. The results of the sensory assessments indicated a notable rise in the Basso, Beattie, and Bresnahan scales, along with a marked decline in delayed reactions, among the subjects who received treatment with silver nanoparticles. The most substantial decrease in GFAP levels was noted in the group that was administered silver nanoparticles. Furthermore, there was a substantial decrease in the size of the cavity regions, while the quantity of ventral motor neurons experienced a significant rise within the silver nanoparticles group. The electromyography (EMG) results demonstrated a remarkable enhancement in the hindlimbs of the subjects who received treatment with silver nanoparticles (50 µg/kg).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
酒玖柒完成签到 ,获得积分10
1秒前
1秒前
称心嫣娆发布了新的文献求助10
2秒前
Owen应助zyf采纳,获得10
2秒前
3秒前
顾矜应助插秧露娜采纳,获得10
3秒前
4秒前
陈强强完成签到,获得积分10
5秒前
Tsuns完成签到 ,获得积分10
6秒前
大喵发布了新的文献求助10
7秒前
啦啦啦完成签到,获得积分10
8秒前
8秒前
9秒前
9秒前
11秒前
12秒前
Mano完成签到,获得积分10
13秒前
小熊饼干发布了新的文献求助10
13秒前
13秒前
奇拉维特完成签到 ,获得积分10
13秒前
zyf发布了新的文献求助10
14秒前
14秒前
15秒前
闪闪如南完成签到,获得积分10
16秒前
16秒前
插秧露娜发布了新的文献求助10
17秒前
Steven发布了新的文献求助10
19秒前
称心嫣娆完成签到,获得积分10
20秒前
漂亮白枫发布了新的文献求助10
21秒前
peanut发布了新的文献求助10
24秒前
一直向前发布了新的文献求助10
25秒前
liziqi完成签到,获得积分10
29秒前
烟花应助漂亮白枫采纳,获得10
32秒前
天才幸运鱼完成签到,获得积分10
32秒前
泡泡应助公冶笑白采纳,获得10
33秒前
华仔应助公冶笑白采纳,获得10
33秒前
恋雅颖月应助公冶笑白采纳,获得10
33秒前
莉莉娅发布了新的文献求助10
33秒前
35秒前
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989797
求助须知:如何正确求助?哪些是违规求助? 3531910
关于积分的说明 11255394
捐赠科研通 3270563
什么是DOI,文献DOI怎么找? 1805008
邀请新用户注册赠送积分活动 882157
科研通“疑难数据库(出版商)”最低求助积分说明 809190