A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions

This study describes the efficient synthesis of quinazolines promoted by TEMPO via electro-catalysis with 2-aminobenzophenones and benzylamines. The method exhibited remarkable chemoselectivity under mild reaction conditions. A series of quinazolines could be obtained in moderate to good yields. In addition, control experiments were carried out to verify the reaction mechanism. Furthermore, the synthesis on the gram scale was conducted successfully to give the target product.