溶剂
水溶液
光化学
溶解度
氢键
溶解
熔点下降
熔点
化学
化学物理
有机化学
分子
作者
Ya‐Ming Tian,Wagner Silva,Ruth M. Gschwind,Burkhard König
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-02-16
卷期号:383 (6684): 750-756
被引量:6
标识
DOI:10.1126/science.adl3092
摘要
Water can accelerate a variety of organic reactions far beyond the rates observed in classical organic solvents. However, using pure water as a solvent introduces solubility constraints that have limited the applicability of efficient photochemistry in particular. We report here the formation of aggregates between pairs of arenes, heteroarenes, enamines, or esters with different electron affinities in an aqueous medium, leading to an oil-water phase boundary through substrate melting point depression. The active hydrogen atoms in the reactants engage in hydrogen bonds with water, thereby accelerating photochemical reactions. This methodology realizes appealingly simple conditions for aqueous coupling reactions of complex solid molecules, including complex drug molecules that are poorly soluble in water.
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