多囊卵巢
表观遗传学
背景(考古学)
药物开发
生物
疾病
药品
医学
生物信息学
遗传学
内分泌学
内科学
药理学
基因
肥胖
古生物学
胰岛素抵抗
作者
Yi Chen,Guiquan Wang,Jingqiao Chen,Congying Wang,Xi Dong,Hsun‐Ming Chang,Shuai Yuan,Yue Zhao,Liangshan Mu
标识
DOI:10.1210/endrev/bnae002
摘要
Abstract The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The US Food and Drug Administration has not approved any drug specifically for treating PCOS. As the significance of genetics and epigenetics rises in drug development, their pivotal insights have greatly enhanced the efficacy and success of drug target discovery and validation, offering promise for guiding the advancement of PCOS treatments. In this context, we outline the genetic and epigenetic advancement in PCOS, which provide novel insights into the pathogenesis of this complex disease. We also delve into the prospective method for harnessing genetic and epigenetic strategies to identify potential drug targets and ensure target safety. Additionally, we shed light on the preliminary evidence and distinctive challenges associated with gene and epigenetic therapies in the context of PCOS.
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