糖皮质激素受体
化学
兴奋剂
交易激励
泼尼松龙
倍他米松
地塞米松
糖皮质激素
IC50型
类固醇
转换抑制
生物信息学
对接(动物)
药理学
受体
内分泌学
内科学
激素
生物化学
转录因子
基因
体外
生物
医学
护理部
作者
Yuan Liang,Zhuolin Li,Jie Zhang,Tiezhu Li,Chengyu Lv
标识
DOI:10.1002/cbdv.202301525
摘要
Over the past decades, the synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given the health hazard of these toxic residues in food, it is necessary to explore the detailed interaction mechanisms of typical GCs and their main target glucocorticoid receptor (GR). Hence, this work compared the GR binding and agonist activities of typical GCs. Fluorescence polarization assay showed that these GCs were potent ligands of GR. Their GR binding affinities were in the order of methylprednisolone>betamethasone≈prednisolone>dexamethasone, with IC
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