瘢痕疙瘩
病因学
疤痕
医学
子宫肌瘤
纤维化
结缔组织
病理
平滑肌瘤
皮肤病科
作者
Gabrielle Hampton,Jeewoo Kim,Todd L. Edwards,Jacklyn N. Hellwege,Digna R. Velez Edwards
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2023-10-01
卷期号:325 (4): C817-C822
标识
DOI:10.1152/ajpcell.00181.2023
摘要
Diseases such as uterine leiomyomata (fibroids and benign tumors of the uterus) and keloids (raised scars) may share common etiology. Fibroids and keloids can co-occur in individuals, and both are highly heritable, suggesting they may share common genetic risk factors. Fibroproliferative diseases are common and characterized by scarring and overgrowth of connective tissue, impacting multiple organ systems. These conditions both have racial disparities in prevalence, with the highest prevalence observed among individuals of African ancestry. Several fibroproliferative diseases are more severe and common in populations of sub-Saharan Africa. This mini-review aims to provide a broad overview of the current knowledge of the evolutionary origins and causes of fibroproliferative diseases. We also discuss current hypotheses proposing that the increased prevalence of these diseases in African-derived populations is due to the selection for profibrotic alleles that are protective against helminth infections and provide examples from knowledge of uterine fibroid and keloid research.
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