生物
干细胞
祖细胞
再生(生物学)
细胞生物学
平衡
祖细胞
上皮
成体干细胞
发育生物学
内皮干细胞
体外
遗传学
作者
Fidelia B Alvina,T Chen,Hui Yi Grace Lim,Nick Barker
出处
期刊:Development
[The Company of Biologists]
日期:2023-09-15
卷期号:150 (18)
摘要
ABSTRACT The stem/progenitor cell pool is indispensable for the development, homeostasis and regeneration of the gastric epithelium, owing to its defining ability to self-renew whilst supplying the various functional epithelial lineages needed to digest food efficiently. A detailed understanding of the intricacies and complexities surrounding the behaviours and roles of these stem cells offers insights, not only into the physiology of gastric epithelial development and maintenance, but also into the pathological consequences following aberrations in stem cell regulation. Here, we provide an insightful synthesis of the existing knowledge on gastric epithelial stem cell biology, including the in vitro and in vivo experimental techniques that have advanced such studies. We highlight the contributions of stem/progenitor cells towards patterning the developing stomach, specification of the differentiated cell lineages and maintenance of the mature epithelium during homeostasis and following injury. Finally, we discuss gaps in our understanding and identify key research areas for future work.
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