WRKY蛋白质结构域
生物
转录因子
心理压抑
拟南芥
Mef2
遗传学
非生物胁迫
细胞生物学
基因
抄写(语言学)
突变体
基因表达
增强子
语言学
哲学
作者
Ping Du,Qi Wang,Dan‐Yang Yuan,Shanshan Chen,Yin‐Na Su,Lin Li,She Chen,Xin‐Jian He
标识
DOI:10.15252/embj.2023113639
摘要
Abstract WRKY transcription factors in plants are known to be able to mediate either transcriptional activation or repression, but the mechanism regulating their transcriptional activity is largely unclear. We found that group IId WRKY transcription factors interact with OBERON (OBE) proteins, forming redundant WRKY‐OBE complexes in Arabidopsis thaliana . The coiled‐coil domain of WRKY transcription factors binds to OBE proteins and is responsible for target gene selection and transcriptional repression. The PHD finger of OBE proteins binds to both histones and WRKY transcription factors. WRKY‐OBE complexes repress the transcription of numerous stress‐responsive genes and are required for maintaining normal plant growth. Several WRKY and OBE mutants show reduced plant size and increased drought tolerance, accompanied by increased expression of stress‐responsive genes. Moreover, expression levels of most of these WRKY and OBE genes are reduced in response to drought stress, revealing a previously uncharacterized regulatory mechanism of the drought stress response. These results suggest that WRKY‐OBE complexes repress transcription of stress‐responsive genes, and thereby balance plant growth and stress tolerance.
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