AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis

Over 38% of both screen-detected and interval cancers were assigned the highest artificial intelligence risk score, on screening mammograms preceding breast cancer diagnosis. Key results:• In this retrospective study of 1602 patients with breast cancer, 38.3% (389/1016) of screen-detected cancers and 39.4% (231/586) of interval cancers had the highest malignancy risk score assigned by artificial intelligence (AI) on the screening mammogram prior to diagnosis.• Mammographic features were associated with AI score 10 (high risk) versus 1-7 (low risk) on prior mammograms for screen-detected invasive cancers (p<0.001).• Among invasive screen-detected cancers with AI score 10 and 1-7 at prior mammograms, density with calcifications were observed for 13.6% (43/317) and 4.7% (15/322), respectively.