急性早幼粒细胞白血病
融合基因
白血病
癌症研究
医学
维甲酸
基因
免疫学
生物
遗传学
维甲酸
作者
Qi Zhang,He Li,Xuelan Chen,Fan Gu,Lanxin Zhang,Lu Zhang,Tong Chen,Qiang Chen,Wentong Meng,Yu Wu,Hong Chang,Ting Liu,Chong Chen,Hongbing Ma,Yu Liu
出处
期刊：Blood
[American Society of Hematology]
日期：2023-10-26
卷期号：142 (17): 1494-1499
被引量：1
标识
DOI：10.1182/blood.2023020619
摘要
Abstract Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
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