An integrated strategy for quality control of Pseudobulbus Cremastrae seu Pleiones based on Q-marker

质量(理念) 计算机科学 传统医学 物理 医学 量子力学
作者
Jiawei Wang,Wu Man,Jiakang Liu,Xudong Mao,Weiqiang Cui,Chun Lei,Chunyue Huang,Xiao Hu
出处
期刊:Journal of Chromatography A [Elsevier]
卷期号:1730: 465105-465105
标识
DOI:10.1016/j.chroma.2024.465105
摘要

Pseudobulbus Cremastrae seu Pleiones (PCsP), a traditional Chinese medicine known as ‶Shan-Ci-Gu″, possesses properties for clearing heat, counteracting toxicity, dissipating phlegm, and resolving masses. As a TCM with multiple bases, the dried pseudobulbs of Pleione bulbocodioides (PB), Pleione yunnanensis (PY) and Cremastra appendiculata (CA) are considered to be the official sources of PCsP. Additionally, several unofficial substitutes are also available in the market. To enhance the quality control of PCsP, an integrated strategy based on Q-marker was proposed. Initially, a study of integrating plant metabolomics, target isolation, structure identification, and activity testing afforded five Q-markers, including three new compounds. Furthermore, a quality evaluation method using a single standard to determine multi-components (SSDMC) based on Q-marker was established, which could effectively distinguish PB from CA and the counterfeit herbs. Finally, the transitivity of Q-markers was explored through a representative Chinese compound prescription containing PCsP. The results indicated that the identified Q-markers together with the established analysis methods could be effectively applied for quality control of PCsP and its preparations.
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