伤口愈合
细菌
透明质酸钠
透明质酸
化学
微生物学
抗菌活性
双重角色
对偶(语法数字)
医学
生物
外科
解剖
色谱法
组合化学
艺术
文学类
遗传学
作者
Xue Li,Yixuan Wang,Linzhi Guo,Xinkai Geng,Haojiang Wang,Anjie Dong,Ruiping Zhang
标识
DOI:10.1016/j.ijbiomac.2024.133423
摘要
Conventional wound dressings are monolithically designed to cover the injured areas as well as absorb the exudates at injured site. Furthermore, antibacterial drugs and growth prompting factors are additionally appended to realize sensible and omnibearing wound management, exhibiting long and tedious treatment process in practice. Consequently, the creation of multifunctional wound dressings that combines wound repair enhancement with antibacterial properties turns out to be significant for simplifying wound managements. In our investigation, electronegative human epidermal growth factor (hEGF) was combined with the positively charged Zn-Al layered double hydroxides (Zn-Al LDHs) via electrostatic interaction while the obtained hEGF/LDH was integrated with sodium hyaluronate hydrogel (SH) hydrogel, forming a composite hydrogel with synergistic benefits for wound management. The innovative hEGF/LDH@SH hydrogel equipped with fine biocompatibility was designed to optimize wound healing in which hEGF stimulates epithelial cell growth while LDH released antibacterial factor Zn
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