Clinical characteristics and risk factors of connective tissue disease complicated with bronchiectasis and pulmonary infection

支气管扩张 医学 内科学 类风湿性关节炎 高分辨率计算机断层扫描 痰培养 血管炎 入射(几何) 队列 胃肠病学 疾病 免疫学 病理 肺结核 物理 光学
作者
Xuan Qi,Jiaying Yang,Hongtao Jin,Yuran Xiao,Ying Wang,Yiqing Zhang
出处
期刊:Apmis [Wiley]
卷期号:132 (8): 571-580
标识
DOI:10.1111/apm.13424
摘要

The clinical data from 118 CTD patients with bronchiectasis were collected and categorized into two groups: pulmonary infection present (n = 67) and absent (n = 51), for comparative analysis of characteristics and risk factors. Then, we analyzed and compared their demographics, disease characteristics, and risk factors for infection. Among the whole cohort (n = 118), the incidence of pulmonary infections was 56.78%. The occurrence of rheumatoid arthritis, systemic lupus erythematosus, and vasculitis was found to be associated with an increased risk of pulmonary infection. Sputum culture identified Pseudomonas aeruginosa and Klebsiella pneumoniae as the predominant pathogens in the infected group. Notably, symptoms such as joint pains (p = 0.018) and morning stiffness (p = 0.017) were significantly more common in the infected group compared to the noninfected group. Moreover, our findings revealed that elevated levels of C‐reactive protein and complement C3, along with bronchial expansion observed on high‐resolution computed tomography (HRCT), were significant independent factors in the infection group. Conversely, pulmonary interstitial changes identified through HRCT (OR: 0.135, 95% CI: 0.030–0.612, p = 0.009) were significantly associated with the non‐infection group. Overall, this study provides valuable insights into managing CTD patients with bronchiectasis, emphasizing early detection and tailored approaches to prevent and treat pulmonary infections for better outcomes.
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