食管鳞状细胞癌
组蛋白
缺氧(环境)
基底细胞
转录因子
抄写(语言学)
癌症研究
细胞生物学
化学
癌
生物
医学
内科学
生物化学
氧气
基因
有机化学
哲学
语言学
作者
Yong Zang,Aiyuan Wang,Jianji Zhang,Mingxin Xia,Zixin Jiang,Bona Jia,Congcong Lu,Chen Chen,Siyu Wang,Yingao Zhang,Chen Wang,Xinyi Cao,Ziru Niu,Chaoran He,Xue Bai,Shanshan Tian,Guijin Zhai,Hailong Cao,Yupeng Chen,Kai Zhang
出处
期刊:iScience
[Elsevier]
日期:2024-07-01
卷期号:27 (7): 110188-110188
被引量:1
标识
DOI:10.1016/j.isci.2024.110188
摘要
Hypoxia promotes tumorigenesis and lactate accumulation in esophageal squamous cell carcinoma (ESCC). Lactate can induce histone lysine lactylation (Kla, a recently identified histone marks) to regulate transcription. However, the functional consequence of histone Kla under hypoxia in ESCC remains to be explored. Here, we reveal that hypoxia facilitates histone H3K9la to enhance
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