信使核糖核酸
体外
病毒
体内
生物
细胞生物学
化学
病毒学
基因
生物化学
遗传学
作者
Sweta Karan,Ana L. Durán-Meza,Abigail Chapman,Cheylene Tanimoto,Soo Khim Chan,Charles M. Knobler,William M. Gelbart,Nicole F. Steinmetz
标识
DOI:10.1021/acs.molpharmaceut.3c01105
摘要
The dramatic effectiveness of recent mRNA (mRNA)-based COVID vaccines delivered in lipid nanoparticles has highlighted the promise of mRNA therapeutics in general. In this report, we extend our earlier work on self-amplifying mRNAs delivered in spherical
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