Low-Cytotoxic Core–Sheath ZnO NWs@TiO2–xNy Triggered Piezo-photocatalytic Antibacterial Activity

材料科学 光催化 生物相容性 抗菌活性 纳米技术 细胞毒性 复合数 纳米材料 复合材料 化学 有机化学 催化作用 冶金 生物化学 生物 细菌 体外 遗传学
作者
Shanhong Guo,Guoqiang Shu,Hongjie Luo,Kuang Xia,Lirong Zheng,Chao Wang,Changan Zhou,Lei Song,Kui Ma,Hairong Yue
出处
期刊:ACS Applied Materials & Interfaces [American Chemical Society]
卷期号:16 (19): 24410-24420 被引量:12
标识
DOI:10.1021/acsami.4c04500
摘要

Sonophotodynamic antimicrobial therapy (SPDAT) is recognized as a highly efficient biomedical treatment option, known for its versatility and remarkable healing outcomes. Nevertheless, there is a scarcity of sonophotosensitizers that demonstrate both low cytotoxicity and exceptional antibacterial effectiveness in clinical applications. In this paper, a novel ZnO nanowires (NWs)@TiO2–xNy core–sheath composite was developed, which integrates the piezoelectric effect and heterojunction to build dual built-in electric fields. Remarkably, it showed superb antibacterial effectiveness (achieving 95% within 60 min against S. aureus and ∼100% within 40 min against E. coli, respectively) when exposed to visible light and ultrasound. Due to the continuous interference caused by light and ultrasound, the material's electrostatic equilibrium gets disrupted. The modification in electrical properties facilitates the composite's ability to attract bacterial cells through electrostatic forces. Moreover, Zn–O–Ti and Zn–N–Ti bonds formed at the interface of ZnO NWs@TiO2–xNy, further enhancing the dual internal electric fields to accelerate the excited carrier separation to generate more reactive oxygen species (ROS), and thereby boosting the antimicrobial performance. In addition, the TiO2 layer limited Zn2+ dissolution into solution, leading to good biocompatibility and low cytotoxicity. Lastly, we suggest a mechanistic model to offer practical direction for the future development of antibacterial agents that are both low in toxicity and high in efficacy. In comparison to the traditional photodynamic therapy systems, ZnO NWs@TiO2–xNy composites exhibit super piezo-photocatalytic antibacterial activity with low toxicity, which shows great potential for clinical application as an antibacterial nanomaterial.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
3秒前
lili发布了新的文献求助200
3秒前
hywei完成签到,获得积分10
4秒前
hanch发布了新的文献求助10
4秒前
4秒前
量子星尘发布了新的文献求助10
6秒前
大模型应助红莲墨生采纳,获得10
6秒前
上官若男应助木又权采纳,获得10
7秒前
123关注了科研通微信公众号
7秒前
Akim应助龙仔采纳,获得10
8秒前
8秒前
整齐的蜻蜓完成签到 ,获得积分10
8秒前
han完成签到,获得积分10
9秒前
zlg发布了新的文献求助10
13秒前
13秒前
13秒前
14秒前
15秒前
16秒前
16秒前
孢子完成签到,获得积分10
16秒前
Xiang发布了新的文献求助10
16秒前
17秒前
星辰大海应助hanch采纳,获得10
17秒前
19秒前
Yep0672发布了新的文献求助10
20秒前
冷艳如柏完成签到,获得积分10
20秒前
红莲墨生发布了新的文献求助10
20秒前
研究僧发布了新的文献求助10
20秒前
顾矜应助无恙采纳,获得10
20秒前
QQQ发布了新的文献求助10
20秒前
123发布了新的文献求助10
21秒前
Cc完成签到 ,获得积分10
22秒前
coco完成签到,获得积分10
22秒前
24秒前
25秒前
hywei发布了新的文献求助10
25秒前
tttt发布了新的文献求助10
25秒前
柯尔丝发布了新的文献求助100
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975953
求助须知:如何正确求助?哪些是违规求助? 3520269
关于积分的说明 11201866
捐赠科研通 3256738
什么是DOI,文献DOI怎么找? 1798436
邀请新用户注册赠送积分活动 877578
科研通“疑难数据库(出版商)”最低求助积分说明 806464