血管生成
新陈代谢
糖酵解
代谢途径
生物
谷氨酰胺
细胞生物学
生物化学
癌症研究
氨基酸
作者
Yun Liu,Zifang Wu,Yikun Li,Yating Chen,Xuan Zhao,Miaomiao Wu,Yaoyao Xia
标识
DOI:10.1016/j.jare.2024.05.001
摘要
Endothelial cell (EC) metabolism plays a crucial role in the process of angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and glutamine metabolism, secure vascular migration and proliferation, energy and biomass production, as well as redox homeostasis maintenance during vessel formation. Nevertheless, perturbation of EC metabolism instigates vascular dysregulation-associated diseases, especially cancer. In this review, we aim to discuss the metabolic regulation of angiogenesis by EC metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism. In this work, we discuss various aspects of EC metabolism considering normal and diseased vasculature. Of relevance, we highlight that the implications of EC metabolism-targeted intervention (chiefly by metabolic enzymes or metabolites) could be harnessed in orchestrating a spectrum of pathological angiogenesis-associated diseases.
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