Stereoselective Synthesis of C-Aryl-α-Glycosides by Reductive C(sp2)-C(sp3) Cross-Coupling Reaction

C-aryl glycosides have attracted considerable interest as biologically active natural products and as O-aryl glycoside mimetics in drug discovery. Here, we describe a straightforward synthesis of C-aryl glycosides via photoredox/Ni dual-catalyzed reductive cross-coupling between glycosyl bromides and aryl bromides. This methodology enables highly α-stereoselective synthesis of C-aryl-glucosides, galactosides, and mannosides.