化学
信使核糖核酸
免疫系统
接种疫苗
活性氧
癌症免疫疗法
癌症研究
药理学
生物化学
免疫疗法
免疫学
医学
基因
作者
Kai Yang,Bing Bai,Jiaqi Lei,Xinyang Yu,Shaolong Qi,Yangfan Wang,Feihe Huang,Zaizai Tong,Guocan Yu
摘要
Lipid nanoparticles (LNPs)-based messenger RNA (mRNA) therapeutics have emerged with promising potentials in the fields of infectious diseases, cancer vaccines, and protein replacement therapies; however, their therapeutic efficacy and safety can still be promoted by the optimization of LNPs formulations. Unfortunately, current LNPs suffer from increased production of reactive oxygen species during translation, which leads to a decreased translation efficiency and the onset of inflammation and other side effects. Herein, we synthesize a lipid-modified poly(guanidine thioctic acid) polymer to fabricate novel LNPs for mRNA vaccines. The acquired G-LNPs significantly promote the translation efficiency of loaded mRNA and attenuate inflammation after vaccination through the elimination of reactive oxygen species that are responsible for translational inhibition and inflammatory responses.
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