Bioavailability enhancement of coenzyme Q10: An update of novel approaches

Abstract Coenzyme Q 10 (CoQ 10 ) is an essential, lipid‐soluble vitamin involved in electron transport in the oxidoreductive reactions of the mitochondrial respiratory chain. Structurally, the quinone ring is connected to an isoprenoid moiety, which has a high molecular weight. Over the years, coenzyme Q 10 has become relevant in the treatment of several diseases, like neurodegenerative disorders, coronary diseases, diabetes, hypercholesterolemia, cancer, and others. According to studies, CoQ 10 supplementation might be beneficial in the treatment of CoQ 10 deficiencies and disorders associated with oxidative stress. However, the water‐insoluble nature of CoQ 10 is a major hindrance to successful supplementation. So far, many advancements in CoQ 10 bioavailability enhancement have been developed using novel drug carriers such as solid dispersion, liposomes, micelles, nanoparticles, nanoemulsions, self‐emulsifying drug systems, or various innovative approaches (CoQ 10 complexation with proteins). This article aims to provide an update on methods to improve CoQ 10 solubility and bioavailability.