Alcohol dehydrogenase-catalyzed oxidation

Alcohol dehydrogenases (ADHs) catalyze the reversible oxidation of primary and secondary alcohols to the corresponding aldehydes or carboxylic acids and ketones, respectively, under mild conditions, which may minimize the environmental impact compared to the traditional chemical counterpart. In this short review, we briefly report recent advances in the development of ADH-catalyzed oxidation employed both as single biocatalysts but also in multienzyme cascades of reactions. Current bottlenecks, prospects, and future outlooks in the field are addressed.