自愈水凝胶
右旋糖酐
明胶
肿胀 的
姜黄素
控制释放
化学工程
化学
热稳定性
共价键
药物输送
高分子化学
流变学
材料科学
有机化学
生物化学
复合材料
工程类
作者
Shizhang Yan,Siyu Wu,Jianxun Zhang,Shuang Zhang,Yuyang Huang,Huaping Zhu,Yang Li,Baokun Qi
出处
期刊:Food Chemistry
[Elsevier]
日期:2023-03-17
卷期号:418: 135966-135966
被引量:38
标识
DOI:10.1016/j.foodchem.2023.135966
摘要
Controlled drug delivery could minimize side effects while maintaining a high local dose. Herein, a hydrogel carrier was prepared by forming dynamic imine bonds between gelatin and oxidized dextran (ODex) of different molecular weights (Mw = 10, 70, and 150 kDa). The morphology, thermal stability, rheology, mechanical properties, and swelling properties of the hydrogels and the controlled release of curcumin were characterized. When dextran with a higher Mw was used, the ODex contained more aldehyde groups, which led to a higher degree of cross-linking, considerably shorter gel time, decreased hydrogel porosity, and well-controlled release of curcumin. In addition, the cross-linked hydrogels exhibited not only high thermal stability but also excellent mechanical properties. However, because the matrix was hydrophilic, the swelling properties of the hydrogels were not significantly affected by the Mw of ODex. These observations suggest an approach for designing nutrient delivery carriers with improved controlled release.
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