沃戈宁
熊果酸
蝙蝠葛甾醇
棕榈酸
化学
黄芩
白杨素
立体化学
生药学
传统医学
类黄酮
抗氧化剂
色谱法
有机化学
脂肪酸
体外
生物活性
生物化学
中医药
化学成分
黄芩
医学
替代医学
病理
作者
Jing Li,Yuanqing Ding,Xing-Cong Li,Daneel Ferreira,Shabana I. Khan,T. J. Smillie,Ikhlas A. Khan
摘要
Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2′-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, scutellaric acid, pomolic acid, ursolic acid, β-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro.
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