Catalytic Asymmetric Alkylation of Aldehydes with Grignard Reagents

Added benefits: Grignard reagents can be employed in the asymmetric alkylation of aldehydes by using a titanium(IV) catalyst derived from binol in the presence of excess titanium tetraisopropoxide (see scheme). The reaction proceeds with a low catalyst loading (2 mol %) and exhibits high enantioselectivity for both aromatic and unsaturated aldehydes and for both alkyl and aryl Grignard reagents. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704963_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.