表观遗传学
生物
转录因子
细胞分化
T辅助细胞
细胞命运测定
基因
抄写(语言学)
遗传学
背景(考古学)
细胞生物学
免疫系统
T细胞
古生物学
语言学
哲学
作者
Christopher B. Wilson,Emily Rowell,Masayuki Sekimata
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2009-02-01
卷期号:9 (2): 91-105
被引量:650
摘要
Naive CD4(+) T cells give rise to T-helper-cell subsets with functions that are tailored to their respective roles in host defence. The specification of T-helper-cell subsets is controlled by networks of lineage-specifying transcription factors, which bind to regulatory elements in genes that encode cytokines and other transcription factors. The nuclear context in which these transcription factors act is affected by epigenetic processes, which allow programmes of gene expression to be inherited by progeny cells that at the same time retain the potential for change in response to altered environmental signals. In this Review, we describe these epigenetic processes and discuss how they collaborate to govern the fate and function of T helper cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI