化学
肽
氨基酸
固相合成
丝氨酸
肽合成
酪氨酸
烷基
组合化学
有机化学
生物化学
酶
作者
Mary MacDonald,Marion Lanier,John R. Cashman
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2010-07-09
卷期号:2010 (13): 1951-1954
被引量:7
标识
DOI:10.1055/s-0030-1258132
摘要
We report the solid-phase syntheses of two series of phosphonylated peptides using Fmoc-protected amino acids. The peptides corresponded to regions containing phosphonylated Ser195 in the active site of butyrylcholinesterase and Tyr411 of human serum albumin. The phosphonylated Fmoc-protected amino acids were used in solid-phase peptide synthesis to prepare the peptides. Fmoc-serine and Fmoc-tyrosine with benzyl ester protection were treated with alkyl methylphosphonic monochloridates to phosphonylate the side-chain hydroxy groups. The phosphonylated peptides were designed to mimic the protein region after exposure of the proteins to organophosphorus agents.
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