猫鼬
糖基化
蛋白质亚单位
白细胞介素10受体,α亚单位
Gα亚单位
乙酰胆碱受体
生物化学
阿尔法(金融)
生物
白细胞介素5受体α亚单位
结合位点
受体
化学
分子生物学
医学
生态学
结构效度
护理部
患者满意度
基因
作者
Orna Asher,Bo Jensen,Monica Lupu‐Meiri,Yoram Oron,Sara Fuchs
出处
期刊:FEBS Letters
[Wiley]
日期:1998-04-17
卷期号:426 (2): 212-216
被引量:10
标识
DOI:10.1016/s0014-5793(98)00341-x
摘要
The mongoose AChR alpha-subunit has been cloned and shown to be highly homologous to other AChR alpha-subunits, with only six differences in amino acid residues at positions that are conserved in animal species that bind alpha-bungarotoxin (alpha-BTX). Four of these six substitutions cluster in the ligand binding site, and one of them, Asn-187, forms a consensus N-glycosylation site. The mongoose glycosylated alpha-subunit has a higher apparent molecular mass than that of the rat glycosylated alpha-subunit, probably resulting from the additional glycosylation at Asn-187 of the mongoose subunit. The in vitro translated mongoose alpha-subunit, in a glycosylated or non-glycosylated form, does not bind alpha-BTX, indicating that lack of alpha-BTX binding can be achieved also in the absence of glycosylation.
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