Based on multi-body system dynamics and fuzzy control theory, this paper researches the Vehicle Dynamic Control (VDC) system, and a multi-body dynamics vehicle model was built up by dint of ADAMS/Car software. A fuzzy controller has been designed for the VDC system under Matlab environment, and the controller can generate a suitable yaw moment which is obtained from the difference of the brake forces between different wheels, so that the target values of the yaw rate and the side slip angle are effectively follow up. The control system has been combined with the full vehicle model by data exchange interfaces between the ADAMS software and the Matlab software, the dynamic response of the vehicle with VDC system was simulated under the typical driving cycle. The results show that the vehicle with the VDC system, which adopts the differential braking fuzzy control logic strategy, can improve vehicle handling stability.