病毒血症
病毒载量
病毒学
病毒
人类免疫缺陷病毒(HIV)
免疫学
队列
医学
核糖核酸
病毒性疾病
生物
内科学
遗传学
基因
作者
John W. Mellors,Charles R. Rinaldo,Phalguni Gupta,Roseanne M. White,John A. Todd,Lawrence Kingsley
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-05-24
卷期号:272 (5265): 1167-1170
被引量:2709
标识
DOI:10.1126/science.272.5265.1167
摘要
The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4 + T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4 + T cells.
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