Firstly, a plastic-damage constitutive model for concrete complying with the laws of thermodynamics is proposed based on continuum damage mechanics theory. The damage constitutive equations, damage evolution equations and plastic deformation of concrete are derived. Secondly, Fiber damage analysis model(FDAM) for RC beam-column member is established by analyzing section of fiber beam column element, which was developed with VUEL subroutine based on ABAQUS/Explicit platform, with the uniaxial damage constitutive relations of concrete proposed in present paper being used. The member damage index is defined, which can describe the nonlinear damage behavior of RC members under any loadings. Accuracy of the model is identified preliminarily by comparing with the analysis results of solid element. Finally, a numerical analysis model based on finite element program ABAQUS combined with the proposed damage model is built to analyze the seismic damage of a high-rise structure, and the structure analysis results are compared to the data from shaking table test.