壳聚糖
点击化学
结合
衍生工具(金融)
水溶液中的金属离子
分子
组合化学
金属
化学
催化作用
材料科学
化学工程
高分子化学
有机化学
数学
数学分析
金融经济学
经济
工程类
作者
Jatesuda Jirawutthiwongchai,Andreas Krause,Gerald Draeger,Suwabun Chirachanchai
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2013-02-11
卷期号:2 (3): 177-180
被引量:22
摘要
Click chemistry is considered to be a good pathway to conjugate chitosan with functional molecules due to the ease of the reaction at room temperature. However, as chitosan forms a complex with metal ions, there is a problem with the existence of metal ions in the derivative. The present work demonstrates that chitosan-oxanorbornadiene can provide metal-free Click by showing the optimal condition to introduce oxanorbornadiene, with 80% substitution, and clarifies model reactions of chitosan with azido-modified substrates for the ligation of bioactive molecules.
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