洛哌丁胺
便秘
植物乳杆菌
胃肠病学
内科学
医学
胃肠道
粪便
益生菌
腹泻
乳酸菌
泻药
化学
生物
食品科学
微生物学
乳酸
细菌
发酵
遗传学
作者
Chuan Li,Shaoping Nie,Ke‐Xue Zhu,Tao Xiong,Chang Li,Joshua Gong,Mingyong Xie
标识
DOI:10.3109/09637486.2015.1024204
摘要
Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg−1) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 107 CFU/mL; NCU116-M, 108 CFU/mL; NCU116-H, 109 CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation.
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