Long-term outcome after arterial ischemic stroke in children and young adults

医学 冲程(发动机) 缺血性中风 动脉缺血性中风 期限(时间) 儿科 结果(博弈论) 心脏病学 缺血 数学 量子力学 机械工程 物理 工程类 数理经济学
作者
Barbara Goeggel Simonetti,Ariane Cavelti,Marcel Arnold,Sandra Bigi,Mária Regényi,Heinrich Mattle,Jan Gralla,Joël Fluss,Peter Weber,Annette Hackenberg,Maja Steinlin,Urs Fischer
出处
期刊:Neurology [Ovid Technologies (Wolters Kluwer)]
卷期号:84 (19): 1941-1947 被引量:114
标识
DOI:10.1212/wnl.0000000000001555
摘要

Objective:

To compare long-term outcome of children and young adults with arterial ischemic stroke (AIS) from 2 large registries.

Methods:

Prospective cohort study comparing functional and psychosocial long-term outcome (≥2 years after AIS) in patients who had AIS during childhood (1 month–16 years) or young adulthood (16.1–45 years) between January 2000 and December 2008, who consented to follow-up. Data of children were collected prospectively in the Swiss Neuropediatric Stroke Registry, young adults in the Bernese stroke database.

Results:

Follow-up information was available in 95/116 children and 154/187 young adults. Median follow-up of survivors was 6.9 years (interquartile range 4.7–9.4) and did not differ between the groups (p = 0.122). Long-term functional outcome was similar (p = 0.896): 53 (56%) children and 84 (55%) young adults had a favorable outcome (modified Rankin Scale 0–1). Mortality in children was 14% (13/95) and in young adults 7% (11/154) (p = 0.121) and recurrence rate did not differ (p = 0.759). Overall psychosocial impairment and quality of life did not differ, except for more behavioral problems among children (13% vs 5%, p = 0.040) and more frequent reports of an impact of AIS on everyday life among adults (27% vs 64%, p < 0.001). In a multivariate regression analysis, low Pediatric NIH Stroke Scale/NIH Stroke Scale score was the most important predictor of favorable outcome (p < 0.001).

Conclusion:

There were no major differences in long-term outcome after AIS in children and young adults for mortality, disability, quality of life, psychological, or social variables.
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