Phase I clinical trial of fixed–dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation

吉西他滨 医学 达卡巴嗪 恶心 胃肠病学 内科学 毒性 抗代谢物 药理学 耐火材料(行星科学) 化疗 外科 天体生物学 物理
作者
J. Buesa,Raquel Losa,Aida Fernández,Marta Sierra,Emilio Esteban,Ángela Díaz,Antonio López‐Pousa,J. Fra
出处
期刊:Cancer [Wiley]
卷期号:101 (10): 2261-2269 被引量:21
标识
DOI:10.1002/cncr.20612
摘要

Abstract BACKGROUND In the current study, the authors set out to determine the dose‐limiting toxicity (DLT) and maximum tolerated dose (MTD) associated with a combination of gemcitabine and dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (ASTS), to obtain preliminary information on the activity of this combination, and to explore possible pharmacodynamic interactions between gemcitabine and DTIC. METHODS Every 2 weeks, 22 patients with refractory ASTS received fixed–dose rate gemcitabine (10 mg/m 2 /min) at escalating doses, which ranged from 800 mg/m 2 to 2160 mg/m 2 , plus 500 mg/m 2 DTIC. Plasma concentrations of gemcitabine and 2′,2′‐difluorodeoxyuridine, along with gemcitabine triphosphate (dFdCTP) levels in peripheral blood mononuclear cells (PBMCs), were evaluated during the course of treatment. RESULTS Grade 3 elevation of transaminase and γ‐glutamyltransferase levels represented the DLT associated with the administration of 2160 mg/m 2 gemcitabine plus 500 mg/m 2 DTIC. This side effect was reversible, rather than cumulative, and did not exceed Grade 3 in its severity. The doses recommended for use in subsequent Phase II studies are 1800 mg/m 2 gemcitabine (administered over the course of 3 hours) and 500 mg/m 2 DTIC. Hematologic toxicity was moderate, and nonhematologic side effects that did not exceed Grade 2 in severity included the following: asthenia (75% of patients), fever (59%), nausea (52%), stomatitis (48%), anorexia (44%), emesis (40%), flulike syndrome (37%), and erythematous rash (26%). Alopecia was common. Intracellular dFdCTP levels, which were evaluated in 6 patients, reached a mean maximum value of 209 pmol per 10 6 cells (standard deviation, 59 pmol per 10 6 cells) at the conclusion of gemcitabine administration. DTIC had a limited effect on the elimination of dFdCTP from PBMCs. Objective responses were observed in 5 of the 19 patients who were evaluable for treatment efficacy. CONCLUSIONS The combination of gemcitabine and DTIC possesses an acceptable toxicity profile and may warrant further investigation in patients with ASTS. Cancer 2004. © 2004 American Cancer Society.

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