偶氮苯
共聚物
化学
甲基丙烯酸酯
两亲性
聚合物
高分子化学
胶束
自组装
苯乙烯
纳米结构
共价键
光化学
有机化学
纳米技术
水溶液
材料科学
作者
Jingyi Rao,Christine Hottinger,Anzar Khan
摘要
Catalytic action of an enzyme is shown to transform a non-assembling block copolymer, composed of a completely non-natural repeat unit structure, into a self-assembling polymer building block. To achieve this, poly(styrene) is combined with an enzyme-sensitive methacrylate-based polymer segment carrying carefully designed azobenzene side chains. Once exposed to the enzyme azoreductase, in the presence of coenzyme NADPH, the azobenzene linkages undergo a bond scission reaction. This triggers a spontaneous 1,6-self-elimination cascade process and transforms the initially hydrophobic methacrylate polymer segment into a hydrophilic hydroxyethyl methacrylate structure. This change in chemical polarity of one of the polymer blocks confers an amphiphilic character to the diblock copolymer and permits it to self-assemble into a micellar nanostructure in water.
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