产肠毒素大肠杆菌
腹泻
霍乱
轮状病毒
医学
囊性纤维化跨膜传导调节器
药品
口服补液疗法
分泌物
囊性纤维化
微生物学
药理学
内科学
免疫学
病毒学
生物
肠毒素
大肠杆菌
人口
卫生服务
基因
环境卫生
生物化学
作者
Eugenio L. de Hostos,Robert K. M. Choy,Tue Nguyen
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2011-08-01
卷期号:3 (10): 1317-1325
被引量:41
摘要
Diarrhea, a disease of poverty and poor sanitation, kills an estimated two million children each year. Oral rehydration therapy is a very simple and inexpensive treatment that has significantly reduced mortality from secretory diarrhea caused by rotavirus, cholera and enterotoxigenic Escherichia coli. The efficacy and adoption of oral rehydration therapy would be enhanced by a drug that reduces fluid loss associated with these diseases and alleviates disease symptoms. Secretion and absorption by the intestine offer a number of potential drug targets to reduce fluid loss. Among these, the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the most attractive because it is the primary driver of secretion in cases of diarrhea caused by enterotoxigenic bacteria. CFTR can be inhibited by both natural products and synthetic small molecules. iOWH032 is a synthetic CFTR inhibitor that has recently entered clinical trials for this indication.
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