Longitudinal Study of Radiographic Spinal Osteoarthritis in a Macaque Model

Abstract Cross‐sectional analyses of naturally occurring spinal osteoarthritis (OA) in primates have shown that age and body mass are significant predictors, but whether or not these relationships hold true in longitudinal evaluations remains unclear. Because spinal OA manifests similarly in humans and monkeys and macaque monkeys age >3 times the rate of humans, macaque models offer opportunities for longitudinal study that are difficult in humans. Our objective was to characterize the longitudinal development over 11 years of spinal OA in 68 Macaca mulatta (41 males, 27 females, aged 11–32 years). Average disc space narrowing (DSN) and osteophytosis (OST) scores were computed for the thoracolumbar spine (T8–L7). Our longitudinal analyses confirmed the cross‐sectional results: age and body mass ( p < 0.001) significantly predicted 50% and 39% of the variability in OST and DSN, respectively. Rates of change in DSN, but not OST, were associated with age at first radiograph. This study represents the first long‐term longitudinal assessment of OA in primates and establishes that the relationship among the covariates in the cross‐sectional and longitudinal approaches is similar. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1152–1160, 2011