亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Serum Phosphate and Mortality in Patients with Chronic Kidney Disease

医学 肾脏疾病 内科学 四分位数 比例危险模型 前瞻性队列研究 人口 磷酸盐 透析 肾病科 肾功能 高磷血症 置信区间 环境卫生 有机化学 化学
作者
Helen Eddington,Richard Hoefield,Smeeta Sinha,Constantina Chrysochou,B. Lane,Robert N. Foley,Janet Hegarty,John P. New,Dónal O’Donoghue,Rachel Middleton,Philip A. Kalra
出处
期刊:Clinical Journal of The American Society of Nephrology [American Society of Nephrology]
卷期号:5 (12): 2251-2257 被引量:202
标识
DOI:10.2215/cjn.00810110
摘要

Higher phosphate is associated with mortality in dialysis patients but few prospective studies assess this in nondialysis patients managed in an outpatient nephrology clinic. This prospective longitudinal study examined whether phosphate level was associated with death in a referred population.Patients (1203) of nondialysis chronic kidney disease (CKD) in the Chronic Renal Insufficiency Standards Implementation Study were assessed. Survival analyses were performed for quartiles of baseline phosphate relative to GFR, 12-month time-averaged phosphate, and baseline phosphate according to published phosphate targets.Mean (SD) eGFR was 32 (15) ml/min per 1.73 m(2), age 64 (14) years, and phosphate 1.2 (0.30) mmol/L. Cox multivariate adjusted regression in CKD stages 3 to 4 patients showed an increased risk of all-cause and cardiovascular mortality in the highest quartile compared with that in the lowest quartile of phosphate. No association was found in CKD stage 5 patients. Patients who had values above recommended targets for phosphate control had increased risk of all-cause and cardiovascular death compared with patients below target. The highest quartile compared with the lowest quartile of 12-month time-averaged phosphate was associated with an increased risk of mortality.In CKD stages 3 to 4 patients, higher phosphate was associated with a stepwise increase in mortality. As phosphate levels below published targets (as opposed to within them) are associated with better survival, guidelines for phosphate in nondialysis CKD patients should be re-examined. Intervention trials are required to determine whether lowering phosphate will improve survival.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郑嘉祺发布了新的文献求助10
3秒前
4秒前
6秒前
郑嘉祺完成签到,获得积分10
8秒前
jyy应助科研通管家采纳,获得10
16秒前
Lucas应助可言菜菜采纳,获得10
38秒前
lili应助korchid采纳,获得50
41秒前
52秒前
步步完成签到,获得积分20
53秒前
55秒前
步步发布了新的文献求助10
57秒前
korchid应助文件撤销了驳回
59秒前
流苏33发布了新的文献求助10
1分钟前
善学以致用应助步步采纳,获得10
1分钟前
无花果应助流苏33采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
Georgechan完成签到,获得积分10
1分钟前
机灵的语堂完成签到,获得积分10
1分钟前
2分钟前
2分钟前
2分钟前
Alien完成签到,获得积分10
2分钟前
Alien发布了新的文献求助10
2分钟前
2分钟前
斯文败类应助袁..采纳,获得10
2分钟前
2分钟前
fredericev发布了新的文献求助10
2分钟前
汉堡包应助科研通管家采纳,获得10
2分钟前
kaka完成签到,获得积分10
2分钟前
2分钟前
王小明发布了新的文献求助10
2分钟前
2分钟前
纯真冰蝶完成签到 ,获得积分10
2分钟前
李健应助TIGun采纳,获得10
2分钟前
嗯哼举报Camille求助涉嫌违规
3分钟前
3分钟前
TIGun发布了新的文献求助10
3分钟前
TG_FY完成签到,获得积分10
3分钟前
高分求助中
LNG地下式貯槽指針(JGA指-107) 1000
LNG地上式貯槽指針 (JGA指 ; 108) 1000
Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms 900
QMS18Ed2 | process management. 2nd ed 600
LNG as a marine fuel—Safety and Operational Guidelines - Bunkering 560
Exploring Mitochondrial Autophagy Dysregulation in Osteosarcoma: Its Implications for Prognosis and Targeted Therapy 526
九经直音韵母研究 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2937087
求助须知:如何正确求助?哪些是违规求助? 2593313
关于积分的说明 6985541
捐赠科研通 2237210
什么是DOI,文献DOI怎么找? 1188115
版权声明 589952
科研通“疑难数据库(出版商)”最低求助积分说明 581613