纹状体
伏隔核
多巴胺能
多巴胺
壳核
癫痫
神经科学
尾状核
受体
多巴胺受体
多巴胺受体D2
遗传模型
海马体
内科学
生物
内分泌学
化学
医学
基因
生物化学
作者
Lidia M. Birioukova,I. S. Midzyanovskaya,Sanna Lensu,Leena Tuomisto,Gilles van Luijtelaar
标识
DOI:10.1016/j.eplepsyres.2004.12.001
摘要
The densities of the dopamine (DA) D1-like and D2-like receptors were studied by autoradiography in brain regions of rats with (WAG/Rij strain) and without (ACI strain) genetic absence epilepsy. The core of the nucleus accumbens in WAG/Rij rats had a lower density of D1-like receptors than in ACI rats, a reduction of both D1-like and D2-like DA receptors was also found for the dorsal striatum (dorsal caudate-putamen). On the other hand, the density of D2-like receptors was higher in cortical (frontal and parietal) regions and lower in the CA3 region of the hippocampus of WAG/Rij, as compared to ACI rats. These results give new information about possible malfunction of the brain dopaminergic system in the WAG/Rij rat model of absence epilepsy. It seems that there are differences between WAG/Rij and other models of absence epilepsy, especially concerning the role of striatum.
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