Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas (Koompassia malaccensis)

Taxifolin ( 1 ) and some flavanonol rhamnosides (neoastilbin ( 2 ), astilbin ( 3 ), and isoastilbin ( 4 )) have been isolated from kempas ( Koompassia malaccensis ).  Our previous research about antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of these compounds have been reported. Now, we carried out the anti-acne and tyrosinase inhibition properties of all four compounds.  Antimicrobial against Propionibacterium acnes , P. acnes lipase inhibitory activity and antioxidant activity were established for anti-acne activity.  Tyrosinase inhibition property was measured using L-tyrosine and L-DOPA as substrate.  The results for anti-acne showed that no antimicrobial activity against P. acnes for all compounds, the best lipase inhibition properties showed on compound 4 with IC 50 about 1.36 mg/ml, and % inhibition for antioxidant at concentration 10 mg/ml are 31.16, 25.64, 28.47, and 31.01% respectively.  Tyrosinase inhibition of compound 1 at concentration 1 mg/ml is 24.12% for monophenolase and 5.18% for diphenolase. Compound 2 has tyrosinase inhibition about 25.95% (monophenolase) and 14.18% (diphenolase) at concentration 1 mg/ml. Compound 3 has tyrosinase inhibition about 27.17% (monophenolase) and 6.23% (diphenolase) at same concentration, while compound 4 has tyrosinase inhibition about 11.17% (monophenolase) and 9.75% (diphenolase).