MXenes公司
脂质双层
膜
纳米材料
磷脂
双层
溶解
材料科学
相(物质)
生物物理学
纳米片
纳米技术
相变
化学
生物化学
有机化学
生物
量子力学
物理
作者
One‐Sun Lee,Mohamed Madjet,Khaled A. Mahmoud
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-08-17
卷期号:21 (19): 8510-8517
被引量:30
标识
DOI:10.1021/acs.nanolett.1c01986
摘要
MXenes, two-dimensional metal carbides or nitrides with multifunctional surfaces, are one of the most promising antibacterial nanoscale materials. However, their putative bactericidal mechanism is elusive. To study their bactericidal mechanism, we investigated the interaction between a MXene nanosheet and a model bacterial membrane by molecular dynamics simulations and found that an adsorbed MXene on a membrane surface induced a local phase transition in a domain where the fluidity of the phospholipid in this domain at room temperature was comparable with that of the gel phase. The domain also showed a denser and thinner phospholipid membrane structure than the peripheral phospholipids. By comparing it with our previous experiments of the bactericidal activity of MXenes, we proposed the leakage of intercellular molecules at the phase boundary defects as a possible bactericidal mechanism of MXenes that leads to cell lysis. This study provides a useful model for tailoring new bactericidal nanomaterials.
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