Timing and efficacy of transjugular intrahepatic portosystemic shunt in patients with pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

医学 经颈静脉肝内门体分流术 内科学 胃肠病学 肝功能 胆红素 吡咯里嗪 回顾性队列研究 吡咯里嗪生物碱 门脉高压 肝硬化 生物信息学 生物
作者
Fan Wu,Jiao Yu,Hongying Gan,Heng Zhang,Deying Tian,Dan Zheng
出处
期刊:Scientific Reports [Springer Nature]
卷期号:11 (1) 被引量:6
标识
DOI:10.1038/s41598-021-01201-w
摘要

There is no specific treatment for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome (PA-HSOS). It is not clear when transjugular intrahepatic portosystemic shunt (TIPS) should be implemented in PA-HSOS patients. This study aimed to evaluate the timing of TIPS using total bilirubin (TBIL) as a measure, and to investigate efficacy of TIPS. We retrospectively analyzed the medical records of 10 PA-HSOS patients, among whom 4 patients had received TIPS (TIPS group), and the remaining patients were assigned to the internal medicine group. In the TIPS group, the TBIL level before TIPS was 84.4 ± 45.2 µmol/L (> 3 mg/dL), and TBIL levels were increased to different degrees after TIPS. With the extension of time, serum TBIL levels gradually decreased, and no liver failure occurred. With regards to the short-term outcomes, 3 patients recovered, 1 developed chronic illness and 0 died in the TIPS group. Moreover, 0 patients recovered, 5 developed chronic illness and 1 died in the internal medicine group. The rank sum test of group design revealed significant differences in clinical outcomes (P = 0.02). It was suggested that when the internal medicine effect of PA-HSOS patients is poor, TIPS should be considered, which is no trestricted to the limit of 3 mg/dL TBIL. It was also found TIPS effectively promote the recovery of liver function and reduce the occurrence of chronicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丰知然应助车访枫采纳,获得10
刚刚
2秒前
杜康发布了新的文献求助10
3秒前
3秒前
方糖发布了新的文献求助10
4秒前
6秒前
8秒前
白什么冰发布了新的文献求助10
8秒前
suolong完成签到,获得积分10
9秒前
追风少年lsl完成签到,获得积分10
10秒前
忧郁中恶发布了新的文献求助10
11秒前
明亮无颜发布了新的文献求助10
11秒前
歆兴欣完成签到 ,获得积分10
11秒前
15秒前
广州城建职业技术学院完成签到,获得积分10
17秒前
思源应助布丁采纳,获得10
17秒前
fanature发布了新的文献求助10
18秒前
科研通AI2S应助ly采纳,获得10
18秒前
科研通AI2S应助gxmu6322采纳,获得10
21秒前
JackMa应助土豆采纳,获得10
21秒前
鼹鼠完成签到,获得积分10
22秒前
23秒前
脑洞疼应助fanature采纳,获得10
25秒前
26秒前
27秒前
我是老大应助Tabby采纳,获得10
28秒前
Grayball应助麦子采纳,获得10
28秒前
辛夷发布了新的文献求助30
28秒前
31秒前
LonelyCMA完成签到 ,获得积分10
32秒前
kelvin完成签到,获得积分10
33秒前
布丁发布了新的文献求助10
33秒前
aaaaa发布了新的文献求助10
35秒前
七七爱学习完成签到,获得积分10
36秒前
科研通AI2S应助科研通管家采纳,获得10
37秒前
领导范儿应助科研通管家采纳,获得10
37秒前
Akim应助科研通管家采纳,获得30
37秒前
领导范儿应助科研通管家采纳,获得10
37秒前
天天快乐应助科研通管家采纳,获得10
37秒前
元谷雪应助科研通管家采纳,获得10
37秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188765
求助须知:如何正确求助?哪些是违规求助? 2838216
关于积分的说明 8018955
捐赠科研通 2501091
什么是DOI,文献DOI怎么找? 1335264
科研通“疑难数据库(出版商)”最低求助积分说明 637492
邀请新用户注册赠送积分活动 605604