Timing and efficacy of transjugular intrahepatic portosystemic shunt in patients with pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

医学 经颈静脉肝内门体分流术 内科学 胃肠病学 肝功能 胆红素 吡咯里嗪 回顾性队列研究 吡咯里嗪生物碱 门脉高压 肝硬化 生物信息学 生物
作者
Fan Wu,Jiao Yu,Hongying Gan,Heng Zhang,Deying Tian,Dan Zheng
出处
期刊:Scientific Reports [Springer Nature]
卷期号:11 (1) 被引量:6
标识
DOI:10.1038/s41598-021-01201-w
摘要

There is no specific treatment for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome (PA-HSOS). It is not clear when transjugular intrahepatic portosystemic shunt (TIPS) should be implemented in PA-HSOS patients. This study aimed to evaluate the timing of TIPS using total bilirubin (TBIL) as a measure, and to investigate efficacy of TIPS. We retrospectively analyzed the medical records of 10 PA-HSOS patients, among whom 4 patients had received TIPS (TIPS group), and the remaining patients were assigned to the internal medicine group. In the TIPS group, the TBIL level before TIPS was 84.4 ± 45.2 µmol/L (> 3 mg/dL), and TBIL levels were increased to different degrees after TIPS. With the extension of time, serum TBIL levels gradually decreased, and no liver failure occurred. With regards to the short-term outcomes, 3 patients recovered, 1 developed chronic illness and 0 died in the TIPS group. Moreover, 0 patients recovered, 5 developed chronic illness and 1 died in the internal medicine group. The rank sum test of group design revealed significant differences in clinical outcomes (P = 0.02). It was suggested that when the internal medicine effect of PA-HSOS patients is poor, TIPS should be considered, which is no trestricted to the limit of 3 mg/dL TBIL. It was also found TIPS effectively promote the recovery of liver function and reduce the occurrence of chronicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
烟花应助阔达的凡采纳,获得10
刚刚
windchaser发布了新的文献求助20
1秒前
fdpb完成签到,获得积分10
1秒前
Angsent发布了新的文献求助10
1秒前
稳重笑南发布了新的文献求助10
1秒前
斯文败类应助仔仔采纳,获得10
2秒前
刘肖完成签到,获得积分10
2秒前
shuguang完成签到,获得积分10
2秒前
小二郎应助段采萱采纳,获得10
2秒前
3秒前
3秒前
sxystc关注了科研通微信公众号
3秒前
稽TR关注了科研通微信公众号
5秒前
1+1应助Flora采纳,获得10
5秒前
Agan完成签到,获得积分10
5秒前
5秒前
kkhenry发布了新的文献求助10
6秒前
7秒前
Li_华发布了新的文献求助10
7秒前
暮霭沉沉应助许庆川采纳,获得10
7秒前
7秒前
桐桐应助Amy采纳,获得10
8秒前
paparazzi221应助树袋熊采纳,获得100
8秒前
科研通AI2S应助Rocky采纳,获得10
9秒前
wang发布了新的文献求助10
10秒前
10秒前
情怀应助挤蘑菇采纳,获得10
10秒前
zcz完成签到,获得积分10
11秒前
11秒前
木鱼完成签到 ,获得积分10
11秒前
11秒前
kkhenry完成签到,获得积分10
12秒前
电小渣发布了新的文献求助10
12秒前
小黄鸭发布了新的文献求助10
13秒前
坦率耳机举报resonliu0827求助涉嫌违规
13秒前
14秒前
lysixsixsix发布了新的文献求助10
14秒前
14秒前
传奇3应助认真的裙子采纳,获得10
14秒前
雷123完成签到,获得积分10
14秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
2024 Medicinal Chemistry Reviews 400
Актуализированная стратиграфическая схема триасовых отложений Прикаспийского региона. Объяснительная записка 360
Dictionary of socialism 350
AI-Driven Alzheimer's Disease Detection and Prediction 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193321
求助须知:如何正确求助?哪些是违规求助? 2842281
关于积分的说明 8038597
捐赠科研通 2506279
什么是DOI,文献DOI怎么找? 1339013
科研通“疑难数据库(出版商)”最低求助积分说明 638583
邀请新用户注册赠送积分活动 607154