Timing and efficacy of transjugular intrahepatic portosystemic shunt in patients with pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

医学 经颈静脉肝内门体分流术 内科学 胃肠病学 肝功能 胆红素 吡咯里嗪 回顾性队列研究 吡咯里嗪生物碱 门脉高压 肝硬化 生物信息学 生物
作者
Fan Wu,Jiao Yu,Hongying Gan,Heng Zhang,Deying Tian,Dan Zheng
出处
期刊:Scientific Reports [Springer Nature]
卷期号:11 (1) 被引量:6
标识
DOI:10.1038/s41598-021-01201-w
摘要

There is no specific treatment for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome (PA-HSOS). It is not clear when transjugular intrahepatic portosystemic shunt (TIPS) should be implemented in PA-HSOS patients. This study aimed to evaluate the timing of TIPS using total bilirubin (TBIL) as a measure, and to investigate efficacy of TIPS. We retrospectively analyzed the medical records of 10 PA-HSOS patients, among whom 4 patients had received TIPS (TIPS group), and the remaining patients were assigned to the internal medicine group. In the TIPS group, the TBIL level before TIPS was 84.4 ± 45.2 µmol/L (> 3 mg/dL), and TBIL levels were increased to different degrees after TIPS. With the extension of time, serum TBIL levels gradually decreased, and no liver failure occurred. With regards to the short-term outcomes, 3 patients recovered, 1 developed chronic illness and 0 died in the TIPS group. Moreover, 0 patients recovered, 5 developed chronic illness and 1 died in the internal medicine group. The rank sum test of group design revealed significant differences in clinical outcomes (P = 0.02). It was suggested that when the internal medicine effect of PA-HSOS patients is poor, TIPS should be considered, which is no trestricted to the limit of 3 mg/dL TBIL. It was also found TIPS effectively promote the recovery of liver function and reduce the occurrence of chronicity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
领导范儿应助夏天再见采纳,获得10
4秒前
大模型应助儒雅如松采纳,获得10
5秒前
yulx001发布了新的文献求助10
5秒前
5秒前
不辞完成签到 ,获得积分10
5秒前
6秒前
7秒前
不要引力发布了新的文献求助10
8秒前
8秒前
细心飞鸟完成签到 ,获得积分10
8秒前
9秒前
洞悉发布了新的文献求助10
10秒前
11秒前
科研通AI2S应助钮卿采纳,获得10
11秒前
Orange应助夏天再见采纳,获得10
14秒前
bkagyin应助筱雨采纳,获得10
14秒前
15秒前
顺心曼雁发布了新的文献求助10
15秒前
科研通AI2S应助缓慢芒果采纳,获得10
17秒前
TYM发布了新的文献求助10
17秒前
科研通AI2S应助夏天再见采纳,获得10
19秒前
xianglily完成签到 ,获得积分10
19秒前
20秒前
20秒前
starksimple完成签到 ,获得积分10
21秒前
baoxiaozhai完成签到 ,获得积分10
23秒前
baoxiaozhai完成签到 ,获得积分10
23秒前
zkk应助夏天再见采纳,获得10
24秒前
24秒前
小龙女发布了新的文献求助20
27秒前
如意友灵发布了新的文献求助10
27秒前
不配.应助夏天再见采纳,获得10
30秒前
高兴吐司发布了新的文献求助10
30秒前
中中发布了新的文献求助30
31秒前
群山完成签到 ,获得积分10
31秒前
32秒前
34秒前
ding应助lfchen采纳,获得10
35秒前
38秒前
郜雨寒发布了新的文献求助10
40秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189569
求助须知:如何正确求助?哪些是违规求助? 2838949
关于积分的说明 8022128
捐赠科研通 2501783
什么是DOI,文献DOI怎么找? 1336023
科研通“疑难数据库(出版商)”最低求助积分说明 637750
邀请新用户注册赠送积分活动 605820